Nintedanib Ethanesulfonate Salt
Nintedanib esylate
CAS: 656247-18-6
Molecular Formula: C31H33N5O4.C2H6O3S
Nintedanib Ethanesulfonate Salt - Names and Identifiers
Nintedanib Ethanesulfonate Salt - Physico-chemical Properties
| Molecular Formula | C31H33N5O4.C2H6O3S |
| Molar Mass | 649.75706 |
| Melting Point | >233°C (dec.) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Form Yellow solid, color Light Yellow to Yellow |
| Color | Light Yellow to Yellow |
| Storage Condition | -20°C Freezer |
| Use | Uses Nidanib Ethylate is the salt form of Nidanib. It is a vascular kinase inhibitor for the treatment of idiopathic pulmonary fibrosis. It can also inhibit the process of angiogenesis that can be used to assist cancer treatment. |
Nintedanib Ethanesulfonate Salt - Upstream Downstream Industry
Nintedanib Ethanesulfonate Salt - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.539 ml | 7.695 ml | 15.39 ml |
| 5 mM | 0.308 ml | 1.539 ml | 3.078 ml |
| 10 mM | 0.154 ml | 0.77 ml | 1.539 ml |
| 5 mM | 0.031 ml | 0.154 ml | 0.308 ml |
Last Update：2024-01-02 23:10:35
Nintedanib Ethanesulfonate Salt - Reference Information
| overview | nidanib ethyl sulfonate is a small molecule inhibitor of multi-receptor tyrosine kinase and non-receptor tyrosine kinase. It was first approved by the U.S. FDA in 2014 and was first developed and sold by Boehringer Ingelheim. It has been approved by the US Food and Drug Administration (FDA), the European Medicines Agency (EMA) and the Agency for Medicines and Medical Devices (PMDA) for the treatment of idiopathic pulmonary fibrosis and approved by EMA for non-small cell lung cancer. |
| application | nidanib ethyl sulfonate is a tyrosine kinase inhibitor that can be used as an API for the treatment of idiopathic pulmonary fibrosis (IPF). |
| Use | Nidanib Ethyl Sulfonate is the salt form of Nidanib. It is a vascular kinase inhibitor for the treatment of idiopathic pulmonary fibrosis. It can also inhibit the process of angiogenesis that can be used to assist cancer treatment. |
| target | TargetValue VEGFR2 (Cell-Free Assay) 13 nM VEGFR3 (Cell-Free Assay) 13 nM VEGFR1 (Cell-Free Assay) 34 nM FGFR2 (Cell-Free Assay) 37 nM PDGFRα (Cell-Free Assay) 59 nM |
| Target | Value |
| VEGFR2 (Cell-free assay) | 13 nM |
| VEGFR3 (Cell-free assay) | 13 nM |
| VEGFR1 (Cell-free assay) | 34 nM |
| FGFR2 (Cell-free assay) | 37 nM |
| PDGFRα (Cell-free assay) | 59 nM |
Last Update：2024-04-10 22:29:15
Nintedanib Ethanesulfonate Salt - Nature
| Solubility | DMSO (Slightly), Methanol (Slightly) |
Last Update：2024-04-10 22:29:15
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Mobile: +86-18621343501
QQ: 2881950922
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Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: Nintedanib Ethanesulfonate (Intedanib Ethanesulfonate) Visit Supplier Webpage Request for quotationCAS: 656247-18-6
Tel: +16314854226
Email: info@bocsci.com
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View History
Raw Materials for Nintedanib Ethanesulfonate Salt
Ethanesulfonic acid
Nintedanib
Methyl 1-acetyl-2-oxoindoline-6-carboxylate
(3E)-1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic Acid Methyl Ester
Nintedanib
Methyl 1-acetyl-2-oxoindoline-6-carboxylate
(3E)-1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic Acid Methyl Ester